I am new to this game, would like some advice on a Thanos 300 point army.

currenly i am using

Thanos
Typhoid mary (V)
Paramedic (R)
Shield Medic (E)
Swat Specialist (V)
Swat Specialist (E)
Shield Sniper (R)
Destiny (R)

I think this could be a fun team if you are using the Shield guys to tie up your opponent. March them into battle and block for Thanos.

At some point it would be nice to use the Shield ability on his ranged attack, but you will have a hard time setting it up. Your opponent will probably try to swarm Thanos and take him out before you can use him.

If you look at the Shield guys as expendable, then they can take some hits, push to move out of the way, and stand next to the enemy to force an attack or a break-away attempt.

Also, try to learn fom this team as you play it. Sometimes you can have success with a huge central figure. Other times you will want to have 2 or 3 mid point figs so you have more options.

Good luck.