If you're just starting out in the game, I would recommend something simple for this format.

With two figures, I would recommend one that can shoot and one that can fight in close. Try to get each one as close to 150 points as possible.

I wouldn't bother with a theme team for this tournament -- to use the theme team prob controls, you'll have to give a token to one of your figures (and can't have used that figure beforehand that turn). And +2 to map choice is almost not worth worrying about.

I would play

SI Namor 150
SI Dr. Strange 149

Total: 299
(Actually, that's a Defenders theme team!)

Or, maybe, instead of Dr. Strange, I'd play:

SI Namor 150
AN SR Green Lantern 145

Total: 295

Gives you two Indom figures, TK with Green Lantern to get Namor in closer, Psychic Blast, and stealth-busting.

Running the Black Hand/Manhunter combo is kinda gutsy for a first run... as has been said, there are pros and cons...

but the biggest con to that pairing is the lack of real reducers. The manhunter doesn't take lumps very well, and granted his withering grasp power is handy, if you're going up against what I suspect you may face, you may want to reconsider.

I will say this: if you have them, perhaps...
Aniv. Sinestro and Lyssa Drak. plenty of boom with gusto.