IN CONTACT WITH CEREBRO: If Professor X is in your starting area, he can draw lines of fire and count Range for his Speed, Attack, and Damage powers from the square of any friendly character with whom he shares a keyword.

So my question is this; Does he gain the benefit of Enhancement in the starting are? Secondly, if he has three PD team mates in front of him and his target is 15 squares away, but the PD guys can see the target, does the target still take a -3 to its defense?

Yes. If the character using Enhancement is adjacent to Professor X, that character can use it to increase the damage value of Professor X's ranged combat attack.

Yes, if the characters using the Police team ability are adjacent to Professor X and they can draw a LOF to the target. There is no distance limitation on the team ability and the adjacency is to Professor X, not the friendly keyword character.

Professor X with Enhancers is just scary-fun! Look for X-men to return to the Wizkids World Championship.