For U, how about "Unus the Untouchable"?

I'll accept it...

Now, just get me a Q, X and Y :)

~JP

And here's V, courtesy of Darkseid's Elite.

Virman Vundabar

Yep, that was my V.

R: Reed Richards / Rocket Red
S: Sue Storm / Stephen Strange / Scott Summers
T: Tomar Tu
U: Unus the Untouchable <Melkhor>
V: Virman Vundabar / Victor Von Doom?
W: Wally West / Wonder Woman / Warren Worthington
X: ?
Y: ?
Z: Zatanna Zatara

Wonder Woman

I think you'll have to make them up.

Question Queen

X-Man, Xorn

Yin-Yang (that's got to be a real superhero somewhere)

Quantum Queen, from the Legion of Super Heroes :)

Quentin Quire from the New X-Men and Phoenix End Song.

yeah Xorn should work for X he onlyhas one name.

Or how about Xax since his name begins and ends with X?

Sadly there are no super heroes or villains that I could find with X or Y. We had a good run fellas.

i guess no one thought about the nasty nate....

Yellowjacket (Hank Pym or Rita DeMara version)
Yellow Claw
Yandroth
Ymir (Asgardian frost giant)

X-Ray (one of the U-Foes)

Yeah, but they don't meet the criteria. We're looking for heroes with the classic super cliche names. E.g. Bruce Banner, Wally West, Matt Murdock.