My favorite 10 based on how much I like the characters in the comics and the sculpts more than playability are (and not in order):
1. Spiderman (Iron Spider just beats out lamp post version in blacjk suit)
2. Angel (danger room starter)
3. Flash (multiple body version ties with the red transparent version)
4. Worlds Finest (bats and supes on one fig)
5. Mysterio (love the transparent head)
6. Invisible girl exp (1/2 transparent)
7. Spiderman 2099
8. Lizard V (aloso a favorite play piece)
9. Superman (Son of Darkseid version)
10. Stardust (just looks great)

I have to break down mine by Universe:

DC:
Black Canary
SR Jay Garrick
V Power Girl
E Dr. Mid-Nite
LE Kendra Saunders
V Stargirl
E Mr. Terrific
E Hourman
Liberty Belle
Atom-Smasher

Marvel:
FF U Wolverine (with Sinister Sculpt replacement)
Colossus
FF V Rogue
E Shadowcat
U Nightcrawler
SR Storm
Ms. Marvel
LE Jessica Drew
Starter The Thing
Starter Invisible Woman

1. LE Skyrider of the Spaceways
2. Gamora
3. Adam Warlock (SI)
4. E Drax the Destroyer
5. V Nova
6. U Thanos (SN)
7. Quasar
8. Mister Mind
9. R Shazam!
10. LE Michael Carter (Origin)

11. LE Justice is Served!
12. Dr. Sivana
13. Rip Hunter
14. Alpha Flight ATA

It is actually "Sentinel of the Skyways"

Skyrider of the Spaceways sounds so retro cool.

1. Wade Wilson
2. Cap N Bucky
3. Devil Dinosaur and Moonboy
4. Stark Armor Spider-man
5. Vet Doom CT
6. Zombies
7. Flashes
8. Generics
9. Chrome pieces (surfer, nova, human torch)
10. Collosals (except for Starro...)

It's lots of things.

This list is a lot more based on which figures I like for sentimental reasons then for playability though I break them all out often:

1. Multiple Man
2. Flash (Icons)
3. Jonah Hex
4. Len Snart LE
5. Longshot
6. Nick Fury (sinister)
7. Shazam (origins)
8. Stargirl
9. Colonel Logan
10. Jakeem Thunder

1. Kyle Rayner, Crisis
2. Superman, V Icons
3. Winter Soldier, Avengers
4. Spiderman, Avengers
5. Ganthet
6. KC Shazam
7. LE Kyle Rayner, Collateral Damage
8. Sinestro Bats
9. Ultimate Hulk
10. Iron Fist, V Fantastic Forces

I have the dial in hand--It reads "Sentinel of the Skyways" on my hand. Do you have some one of a kind variant? ::

My list, in no well thought-out order:

E-2 Superman
OoTS Batman
Or Shazam (Rookie, mainly, though the vet deserves respect).
Cr Kid Flash
KC Flash
KC Green Lantern
Destiny
Cr Darkseid
Unl Green Lantern/Hal Jordan
Dr. Strange

1. M&M colossus
2. Sinister U Wolverine
3. NGN Rampaging Hulk
4. M&M Gambit
5. Crisis Mary Marvel
6. Vet havok
7. Sinisier Spider-Man
8. Sinister Radioactive Man
9. BiBTB Venom
10. DC Giants Chemo

CR KC Superman
SN Zombie Wolverine
SN Zombie Hulk
SN Zombie Spider-Man
SN Zombie Colonel America
M&M Green Scar
AV Silver Surfer
MM V Spider-Man
JL Batman (OOTS)
AA Joker

Bear in mind that this list would probably change by the day.

Now, the V Spidey from Sinister is tied with his Iron and 2099 versions.
I just can't decide which one...
Actually i decided that i'd take a separate top 5 Spideys with the rest (Magneto or Super Skrull can take his position)!

1- Spider 2099
2- Iron Spider Avengers
3- Spiderman V SIN
4- Armor Spider LE SIN
5- Spiderman V CM (for his classic pounce look!)

And i even had to leave a runner up: Armor Wars House of M Spidey...

Dude, this top 10 thing... just can't be done

If i could keep only one piece, that would be easy though - Supernova Thanos!
I had never seen so much terror in an opponent's face before i started fielding him!
I had games that people wouldn't even dare shoot him
He's such a beast, and won me a tournament alone.
My totally favourite character AND clix!

1. V Vertigo
2. U Longshot
3. NGN Iron Man
4. V Cyclops (IC)
5. V Shadowcat (Sin)
6. 2099 Hulk
7. U Magneto (AW)
8. V Spymaster
9. V Karma (w/Mental Shields)
10. V Logan

Honorable Mention: Dark Phoenix (I personally think this is the best sculpt WizKids ever put out)

Fairly obvious that I'm an X fan. Most of these are just favorite characters (Logan, Shadowcat), but there are a few that I just have great success with (Cyclops, Magneto). Vertigo is my sentimental vote, I once took out Ult Hulk with her one on one. Longshot is just annoying for the opponent and a great tie-up piece. NGN Iron Man is far and away my favorite armor variation. 2099 Hulk should be awesome, but just not for me (still my vote for most accurate Hulk dial even if I can't seem to use it). Spymaster and Karma are just killer for their cost.

1) OotS Batman
2) Crisis Nightwing
3) Sinister V Spider-Man
4) Sinister Wolverine
5) Origin V Hawkman
6) Crisis Green Lantern
7) Ultimates V Captain America
8) FF V Hawkeye
9) SI Namor
10) Ultimates V Punisher