When I first saw Disintegrate, I thought "Oh, sweet! I can have Omni-Man HSS in to smack my opponent's big-gun and blow up their object at the same time!" but after looking at the card again, this is seemingly not the case.

So, what does Disintegrate work with - and what doesn't it?

Disintegrate will not work with Hypersonic because you can only make a close combat attack. The card says it'll activate with a Close Combat Action.

Which, in turn, means you can Disintegrate while using the follwing powers:
Flurry
Leap/Climb (CC attack against figure on other elevation)
Charge
Mind Control (Close Combat variety - there is no spoon...)
B/C/F
Quake
Incapacitate (Close Combat variety)
Telekinesis (Close Combat variety, to move an opposing figure)
Exploit Weakness
And also straight up stationary attacks, which in turn may utilize Super Strength or Steal Energy.

You can NOT Disintegrate in conjunction with:
HSS
CCE
Pounce
and probably other feats.