First things first, Jack T. Chance "To all you who are wicked, evil and mean, I'm the nastiest creep you ever seen! YOWZA!"

secondly talk here about any flavour text/ card flavour you find totally awesome.

Parademon from Crisis,

You killed Clown!

I like dill, with a splash of Kang

Kang does have some good cards, flavor text wise...

"I am not human? Phah! As if being human was desirable! I am KANG! And that is better than being human!"

Have a Blast!!!

"Someties, you just have to listen to that little voice in your head......and blow things up."

Definitely in the top five for regular cards.

Do the extended/alternate art cards count?. Kind of an unfair comparison if so.

Detective Chimp,shoeless Gumshoe

"everyone Sucks But Me"

My personal favorites (well, those I can think of), in order:

Shadowcat - Katya (MXM 024): "I've been an X-Man since I was fourteen, Pete. It's like wearing a big sign saying "Please try and kill me. I like it.""

Batman - The Dark Knight (DOR 005): "Tell all your friends. Tell them they're finished. Tell them the streets belong to the Batman."

Bizarro - Imperfect Duplicate (DSM 062): "Goodbye! Bizarro no fight you! Bizarro lose!"

Batman - Vengeance (DBM 002): "I am vengeance. I am the night. I am Batman!"

It's Clobberin' Time (MOR 072): ""Say it, Thing."
"Say what?"
"You know what."
"I'm not gonna say it.""

Stargirl - Courtney Whitmore (DCR 023): "Write this to your mom: 'Dear Mom--Got my butt kicked today!'"

Aunt May - May Parker (MSM 032) : "Who wants pie?" (always recited before exhausting her to play Finishing Move:laugh: )

Kang - Kang Cobra (MAV 169): "You thought you were the Master of Time and Kang would consent to be a mere warlord in your court . . . but Kang is the Master here and you are only his pawn!"

Jean Grey - Red (MXM 013): "You're talking to the woman who'se been killed, cloned, and kidnapped more times than even I can remember!"

Detective Chimp, FTW! No question.

Betrayal:

"Charles, your idea of peace with the humans is nothing more then a dream. That dream ends now."

Garth:

"I have been trained by Atlan himself. I command magics you cannot hope to withstand."

Deathstroke The Terminator:

Ref: Ntt\1-2 "When you absolutely, positively have to kill every superhero in the room."

those are best to me by far

Batman, caped crusader : "Out of the grips of violence, Justice is born"

Superman, MoS : "He knows he cannot save them all. And still He tries."

Hunter Zolomon : "Youaaaaregettinnnnnngslowoldmmmannnnn."

SpiderMan, Cosmic Spider : "With cosmic powers come cosmic responsibilities"

...among others i can't think of right now

Midnight Cravings: Mmmm....cookies.

Green Arrow, Emerald Archer: "I never aim, but then again, I never miss."

Hal Jordan, Parallax: Power corrupts. Absolute power is Parallax.

Membership Drive: You got powers? You look like you got powers...

Friendly Fire: “Flame off, Torch! Do you hear me? Flame off, or I’ll pulverize you.”

Devil's Due: "I want that power. By right, it is mine. For ultimate power is the ultimate destiny of Doom!"

Dark Phoenix: "I am ravenous. Before I go on, I need sustenance. This star should do nicely."

Spiderman, New Fantastic Four: With fantastic power comes fantastic responsibility.

The Plunder Plan :
Step 1. Grab stuff
Step 2. Cheese it
Step 3. Profit

And of course, Mr Mxzy ~ Troublesome Trickster:
"Nice try aquaman, but your made of sand!"

Edit: Oh and of course, before I forget
Dr. Sivana:
"I am the rightful ruler of the universe, and no teenaged brat is going to stop me!"

Fatality: Flawless Victory, Finish him

Stargirl and Jubilee.

I like the two Mr. Terrifics. The 1-drop Terry Sloane says something about playing hard but playing fair so no one gets hurt. Then, 3-drop Michael Holt references him by saying "Terry used to say no one had to get hurt. Was he a simpler man or was it just a simpler time?"