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The others are right, but I wanted to add that even for those special Poisons that deal penetrating damage, they would have no effect against someone with Invincible unless it dealt 2 damage (which only a couple figures can do).
-Heroclix is not a game of logic, it's a game of strategy .... after all, when's the last time that you saw a giant (using a stealth ability) that was hiding behind a swingset... and nobody could SEE him????