MENTALLY CONTROLLED TENTACLES: When he makes a close combat attack Doctor Octopus can use Giant Reach: 3 and Improved Targeting: Ignores Characters. Give him a power action to make 4 close combat attacks that deal 2 damage. After actions resolve modify the defense value of any character hit more than 2 times by these attacks by -2 until your next turn

The damage would appear to be locked but just wondering if these would be affected by the Damage Depletion Modifier?

Yes and no.

http://www.hcrealms.com/forum/showthread.php?t=566118


Also there is a search function for the forums to use to see if a question has already been asked.

My phone wasn't allowing me to use the search function. I'll just use my computer from now on.