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Using the game effect (exhausting an adjacent support row character of the same affiliation) can only be done to a defender, but effects such as Burn Rubber can be done anytime unless it specifies "defender".
It doesn't break any rule. You can only "reinforce" a character (exhausting the support row character...etc.) if it is a defender. You can give any character the "reinforced" characteristic, however, thru another effect.