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It varies depending on the characters, plot twists, locations, and equipment you need. If you have a tutor card you can run less characters, because they can easily be found. In equipment decks you need to find room for the equipments you need. With gimmick decks you need all the cards that the gimmick depends on. It all depends on what you need.
There is no set numbers, you just need to play around with your build until you find something that works. Use the Deck Garage forum if you need advice.
If u play a deck with tutors (Signal flare, Mountain stronghold, faces of doom, opitron, underworld star, etc.) u are generally going to have fewer characters maybe 28 characters to 32 other cards.