Okay, if I have a Have A Blast! in my resource row or in my hand and my opponent flips face-up a location or ongoing Plot Twist, can I chain Have A Blast! to the activation of that and destroy it before the effect takes place? What about if the location has an Activate > and needs to be exhausted in order to use it's effect, can I hit it with Have A Blast! before they have a chance to use its effect?

Thanks,
DK69

Once effects are on the chain, they do not care if the source of the effect is removed.

That is, if an opponent uses Avalon and you Blast it, the effect still goes through.