I'm very interested in this, because I just got my first political pressure card today and used it to win twice in one tournament. This and unmasked are currently tied as my picks, because a lot of decks rely on power-ups.

For new players, a "silver bullet" card is a card that, when played against the right deck, will decrease that deck's chances of winning by at least 50%.

Slaughter Swamp used offensively.

Mephisto, Soulstealer

I favor Total Anarchy to help answer the many swarmers in the meta, but not every deck will be well served by it. It's best suited for curve decks that want an edge against rushers.

abra kadabra against CS.

reconnaissance or maybe pinned both are uber broken

Flame trap is the best silver bullet as it can be used against curve and owns rush if able to use.

i say this cuz of stupid fixer.

I have never seen a card that hoses several of the tier 1 decks like Psimon does.... assuming they live that long.

Blackout against Injustice Gang.

Flame Trap, because it can win games all by itself.

Unmasked.

Null Time Zone.

It's multi-purpose.

Flame Trap and Total Anarchy, Hands down.

I couldn't have said it better myself. Anarchy to stop the decks like Titans and Dr Light. Null time zone to stop all the combo/control tricks (paralysis, reign, cover fire, valeria, cosmic radiation, etc)

Phantom Zone.